Human Sera
Cayman Chemical 1R 3S3AmInocyclopentnol 100mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical 2mthylaPyrroldInopropIop 50mg
Shares structural features with the stimulant α-PPP and is a positional isomer of 4'-methyl-α-PPP (hydrochloride), which has been detected in bath salts and other formulations; this product is intended to be used for forensic and research applications
Cayman Chemical LeupeptInhemIsulfate 100mg
A reversible inhibitor of cysteine, serine, and threonine proteases; inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin
Cayman Chemical MethIdathIon 100mg
An organophosphate insecticide; inhibits insect cholinesterase; reduces cattle lice (L. vituli, D. bovis, and H. eurysternus) infestation by 99.1% at 3.5 mg/kg; selectively toxic to lice over cattle, only inhibiting cattle plasma acetylcholinesterase activity by 20% with no effect on survival at 24 mg/kg; increases SCE and induces cell cycle arrest at the M1 phase in V79 cells at 40 μg/ml; increases liver enzyme activity, inhibits cholinesterase, and induces chronic liver inflammation in male beagle dogs from 1.4-4.7 mg/kg; induces loss of striation and myocytolysis of cardiomyocytes and reduces serum cholinesterase activity in rats 5 mg/kg
Cayman Chemical 123 TrIlnolaIdoyl GlycRo 50mg
A triacylglycerol; dietary administration lowers serum levels of TXB2, PGF2, and PGE in rats from 0.6-6.3% w/w
Cayman Chemical LIxIsenatIdeacetate 50mg
A GLP-1R agonist; binds to CHO-K1 cells expressing human GLP-1R (IC50 = 1.4 nM); inhibits Il-1β- and IFN-γ-induced apoptosis in INS-1 rat pancreatic β-cells at 100 pM; lowers blood glucose levels in an OGTT (ED50 = 0.021 nmol/kg) and decreases blood HbA1c levels in db/db mice
Cayman Chemical 10methyl9 phenoxycarbonyl 50mg
An acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions; can be used in chemiluminescence assays, enzyme, antigen, antibody, and hormone immunoassays, and assays to detect oxidants in environmental, biological, and pharmaceutical samples
Cayman Chemical IsovalerylLcarnItInchlor 100mg
A naturally occurring acylcarnitine; formed via metabolic conversion of L-leucine; increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes at 1 mM; inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver at 77 and 100 μM, respectively
Cayman Chemical DegarelIxacetate 50mg
A synthetic GNRHR antagonist (IC50 = 3 nM in HEK293 cells expressing the human receptor); inhibits the growth of WPMY-1, WPE1-NA22, BPH-1, and LNCaP prostate cell lines via caspase activation and induction of apoptosis (10 μM); decreases plasma testosterone levels in rats to castrate levels for the first 49 days post treatment (2 mg/kg); decreases tumor volume of Dunning R3327H prostate tumor flank implants in rats (1 mg/kg per month)
Cayman Chemical OxtrIphylIn 50mg
A choline salt form of theophylline; decreases histamine-induced contractions of isolated guinea pig trachea; increases cAMP levels in guinea pig tracheal smooth muscle cells in vitro
Cayman Chemical KnamycIn B 100mg
An aminoglycoside antibiotic; active against S. aureus, E. coli, P. aeruginosa, and P. rettgeri(MICs = 0.78-25 UG/ml); binds to the ribosomal decoding A site to interfere with bacterial protein synthesis
Cayman Chemical PnobInostat 50mg
A pan-HDAC inhibitor (Kis = 0.6-31 nM for HDAC1-11); inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including SCLC, NSCLC, and mesothelioma cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively); induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models at 20 mg/kg i.p.
Cayman Chemical SerotonInhydrochlorIde 100mg
A monoamine neurotransmitter produced in serotonergic neurons in the CNS and in enterochromaffin cells in the gastrointestinal tract that is important in the regulation of mood, sleep, vomiting, sexuality, and appetite
Cayman Chemical N 3pyrIdylIndomethacIn am 50mg
N-3PyIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 52 nM. It is about 1,300 times less potent as an inhibitor of ovine COX-1.{8243} However, N-3PyIA does not distinguish between ovine COX-1 and -2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.{8513}
Cayman Chemical 3 4DIhydroxyphenyl ethnol 50mg
3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 µM, respectively. It does not inhibit, and may actually enhance, COX activity.{4049} 3,4-Dihydroxyphenyl ethanol also protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis.{6597}